The combination of Lincomycin and Spectinomycin can act either additively or, in some cases,
synergistically. Spectinomycin’s effectiveness ranges from bacteriostatic to bactericidal, depending
on the dosage, primarily against Gram-negative bacteria like Campylobacter, E. coli, Salmonella
spp., and Mycoplasma. Lincomycin, on the other hand, demonstrates bacteriostatic or bactericidal
activity, predominantly against Gram-positive bacteria such as Staphylococcus, Streptococcus,
Treponema spp., and Mycoplasma. It’s worth noting that cross-resistance between lincomycin and
macrolides is possible.