The combination of Trimethoprim and Sulfadiazine demonstrates synergistic and typically
bactericidal effects against a wide range of Gram-positive and Gram-negative bacteria, including
E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus, and Streptococcus spp. Both
compounds impact bacterial purine synthesis through different mechanisms, resulting in a dual
blockade.